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Cilnidipine (FRC-8653,Atelec?, Cilaheart?, Cilacar?)西尼地平
| 貨號(hào) | IIC1158 | 售價(jià)（元） | 1245 |
| 規(guī)格 | 10mg | CAS號(hào) | 132203-70-4 |
- 產(chǎn)品簡介
- 相關(guān)產(chǎn)品
貨號(hào)
名稱
規(guī)格
價(jià)格
IIC1158-0010MG
Cilnidipine
10MG
1245
IIC1158-0050MG
Cilnidipine
50MG
5029
產(chǎn)品簡介：
西尼地平(FRC8653)是一種L型和N型雙重鈣通道阻滯劑，具有抗高血壓、抗交感神經(jīng)和神經(jīng)保護(hù)活性。IC50值:目標(biāo):鈣通道西尼地平在高血壓患者中顯示出腎臟和血管保護(hù)作用以及改善的壓力反射敏感性。它還通過清除自由基和激活磷脂酰肌醇3-激酶途徑，在大鼠局灶性腦缺血模型中表現(xiàn)出神經(jīng)保護(hù)作用。
產(chǎn)品性質(zhì)：
Cas No.:132203-70-4
別名:西尼地平; FRC-8653
化學(xué)名:3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC
分子式:C27H28N2O7
分子量:492.52
溶解度:≥ 24.6mg/mL in DMSO
儲(chǔ)存條件:4°C, protect from light
注意事項(xiàng)：
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References:
[1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10
[2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83.
[3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91.
[4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10.